Comparison between topical application of Honey, Bees wax and Olive Oil Propolis extract and Nystatin for treatment of Diaper Dermatitis in Infants

Diaper dermatitis (DD) is the most common dermatological disorder in infants. It is frequently secondarily infected with Candida albicans. Objective: To assess the efficacy and clinical outcome of honey, bees wax and olive oil propolis extract mixture and Nystatin cream as treatment regimen in diaper dermatitis. Methods:A total of 76 infants with diaper dermatitis were randomly treated with either Honey mixture (n=37) or Nystatin cream (n=39). Symptom Score (SS) was assessed at base line before treatment, at 5 and 10 days after treatment. Candida culture was done before treatment and on the fifth day after treatment. Results: Symptom Score was significantly decreased more in Honey mixture than in Nystatin(P=0.04),(P=0.001) at 5 and 10 days respectively. At 10 days after treatment, Honey mixture showed statistically significant higher proportion of complete recovery (94.6%) compared with Nystatin(64.1%) (P<0.002). Microbiological cure rate was 100% with Nystatin, while 72.4% with Honey mixture (P=<0.001). Conclusion: Honey mixture was superior to Nystatin in recovery of symptoms at 10 days. Honey mixture might be used alone or as adjuvant therapy in treatment of Diaper Dermatitis in infants.